Advantage Spot-On Flea Treatment for dogs over 25kg (400mg) comes in a pack of 4 pipettes. Fleas can cause significant irritation and health problems for dogs, including flea allergy dermatitis (FAD) and anaemia. Some dogs develop allergies to flea saliva, leading to severe itching and skin infections. Infected fleas can also transmit tapeworm if ingested during grooming. Fleas can also bite humans and infest homes, making eradication a lengthy process as only 5% of fleas are on the pet, while the remaining 95% are in the home environment as eggs, larvae, and pupae. Advantage, recommended by vets, offers a quick and easy pipette application that starts working within one day and provides protection for up to four weeks. It kills fleas on contact, meaning they don't need to bite your dog to be killed. Advantage also treats biting lice. To use, part the fur on the dog's back from the shoulder blades to the base of the tail and apply the contents of the pipette to 3-4 spots directly onto the skin. For dogs weighing between 25kg and 40kg, one pipette is sufficient. For dogs 40kg and over, two pipettes are recommended. Each pipette contains 400mg of Imidacloprid.