Denamarin provides multi-faceted high-level nutritional support for the liver due to its synergistic combination of S-adenosylmethionine (SAMe) and silybin. It is available in three sizes to make it easy to give to your cat or dog: For cats and small dogs up to 5kg, for medium dogs 5-15kg, and for large dogs over 15kg. The coated tablet protects the SAMe from degradation and is blister-packed to prevent oxidation. For best absorption, administer on an empty stomach or at least 2 hours after feeding and wait 1 hour before feeding again. Each Medium Dog Pack contains SAMe 225mg and Silybin 24mg.