Manevac Granules are a stimulant laxative used to treat constipation by encouraging bowel contractions. They work by stimulating nerve endings in the large bowel, increasing the frequency and force of muscle contractions to help regulate bowel movements. Causes of constipation can include dietary changes, insufficient fluid intake, pregnancy, lack of exercise, and certain medications like those containing morphine or codeine. While effective for short-term relief, incorrect or prolonged use can lead to imbalances in electrolytes and minerals (sodium, potassium, magnesium), potentially affecting heart and colon function. Severe dehydration can result in tremors, blurred vision, weakness, kidney damage, fainting, and in extreme cases, death. Overuse may also cause the colon to become less responsive to laxatives, requiring higher doses. The British National Formulary (BNF) provides detailed information on Manevac Granules, including ingredients and dosages, accessible to healthcare professionals and the public. Manevac Granules were temporarily discontinued between September 2020 and February 2021 due to supply chain issues but are now available again. They are sold over-the-counter; ensure purchases are from legitimate pharmacies. A 400g pack is also available, differing from the 250g size. For adults and children over 12, the typical dosage is one to two level measuring spoons or sachets (5g or 10g) taken once daily at night, at least 30 minutes to an hour before or after other medications, and not immediately before bed. The maximum daily dose is 10g. It is recommended to take Manevac Granules up to three times a week for no longer than one week. The product is not recommended for children under 12 with constipation, and treatment for this age group requires different approaches. If more than the recommended dose is taken, seek immediate medical advice.