Dietary Supplement. Gluten Free. Supports Circulation and Heart/Vessels. Significant research supports the cardiovascular benefits of L-arginine in promoting vascular health and blood flow. L-arginine enhances nitric oxide production in the arteries, which in turn relaxes blood vessels and maintains healthy blood flow. Thorne's L-Arginine Plus, with nutrients for added support, combines sustained-release L-arginine with nutritional cofactors that enhance nitric oxide synthesis in the blood vessels (5-MTHF and ascorbic acid), in addition to antioxidants and botanicals that promote normal blood flow (R-lipoic acid, green tea extract, and resveratrol). Thorne's L-Arginine is available for individuals who only want to supplement with L-arginine. L-arginine is a semi-essential amino acid that is involved in multiple areas of human physiology and metabolism. It has a significant effect on endocrine function and helps regulate the release of neurotransmitter chemicals, insulin, glucagon (which has the opposite effect of insulin; i.e., it raises blood sugar), and growth hormone. However, one of L-arginine's most compelling contributions to human physiology is its role as a biological precursor of nitric oxide. The lining of the arteries (the vascular endothelium) creates nitric oxide from L-arginine, resulting primarily in the relaxation of the blood vessels. This process is important to maintaining good vascular health, heart health, reproductive health, and protection against oxidative damage. Maintaining the healthy vascular endothelium function depends on an adequate supply of L-arginine being available to these cells. Without adequate L-arginine – and the subsequent production of nitric oxide – available to the vascular endothelium, arteries don't optimally dilate, which results in less than optimal blood flow to the organs and extremities. Thorne's L-Arginine Plus is a high-quality supplement providing the amino acid L-Arginine, known for its role in nitric oxide (NO) production and cardiovascular health. This bottle contains 180 capsules, each designed to support heart health, circulation, and muscle metabolism. L-Arginine is also popular among athletes for its potential to enhance physical performance and recovery. Key Features: Each capsule provides L-Arginine, an amino acid that supports nitric oxide production. Promotes cardiovascular health and improved blood flow. Supports muscle metabolism and recovery. Ideal for athletes and individuals seeking cardiovascular support. Free from gluten, soy, dairy, and artificial additives.