Crypto is back and this time he has brought a friend! That's right, the much anticipated follow up to Pandemic's 2005 hit, Destroy All Humans! allows two homicidal Furons to cry havoc and let slip the anal probes of war. As in the first game, world domination is your goal. However, this time Crypto's mother ship has been destroyed by the KGB and Orthopox has been killed. That hasn't stopped him from berating Crypto, though. The tricky Furon leader has managed to upload himself into a portable holographic projector from where he can direct the missions that are required to conquer the Earth. The game plays much the same.